Pharmacodynamics enrofloxacin ndi yotakata sipekitiramu bactericidal mankhwala fluoroquinolone nyama. Zimakhala ndi zotsatira zabwino pa escherichia coli, salmonella, klebsiella, brucella, pasteurella, actinobacillus pleuropneumoniae, erysipelas, proteus, serratia marcescens, corynebacterium pyogenes, portococcus septicus, staphylococcus aureus, mycoplasma ofooka, mycoplasma, etc. aeruginosa ndi streptococcus, ndi mphamvu yofooka pa mabakiteriya anaerobic. Zili ndi zotsatira zoonekeratu za post-antibacterial pa mabakiteriya okhudzidwa. The antibacterial limagwirira cha mankhwalawa ndi ziletsa bakiteriya DNA kasinthasintha enzyme, kusokoneza bakiteriya DNA kugawanika, transcript ndi kukonza recombination, mabakiteriya sangathe kukula ndi kubereka bwinobwino ndi kufa.
Pharmacokinetics mayamwidwe mu mnofu wa mankhwalawa ndi mofulumira komanso kwathunthu, ndi bioavailability wa 91.9% mu nkhumba ndi 82% mu mkaka ng'ombe. Amagawidwa kwambiri mu nyama ndipo amatha kulowa m'matumbo ndi madzi amthupi bwino, kupatula cerebrospinal fluid, kuchuluka kwa mankhwala pafupifupi m'magulu onse ndi apamwamba kuposa a plasma. Chiwindi kagayidwe makamaka kupanga ciprofloxacin pochotsa ethyl wa 7-piperazine mphete, kenako makutidwe ndi okosijeni ndi glucuronic acid kumanga. Imatulutsidwa makamaka ndi impso (mwa kutulutsa kwaimpso ndi kusefera kwa glomerular), ndipo 15% mpaka 50% imachotsedwa mumkodzo momwe idayambira. Kuchotsa theka la moyo kumasiyana kwambiri mumitundu yosiyanasiyana komanso njira zosiyanasiyana zoyendetsera. Theka la moyo pambuyo jekeseni mu mnofu 5.9 maola ng'ombe, 9.9 maola akavalo, 1.5 4.5 maola nkhosa, ndi 4.6 maola nkhumba.
1. Mankhwalawa amakhala ndi synergistic akagwiritsidwa ntchito ndi aminoglycoside kapena ma penicillin ambiri.
2. Ioni zachitsulo zolemera monga ca2+, mg2+, fe3+ ndi al3+ canchelate ndi mankhwalawa ndipo zimakhudza kuyamwa.
3. Pamene pamodzi ndi theophylline ndi caffeine, akhoza kuchepetsa kumanga mlingo wa plasma mapuloteni, abnormally kuonjezera ndende ya theophylline ndi tiyi kapena khofi m'magazi, ndipo ngakhale kuoneka theophylline poizoni zizindikiro.
4. Izi mankhwala ndi zotsatira za inhibiting chiwindi mankhwala michere, amene angathe kuchepetsa chilolezo mlingo wa mankhwala zimapukusidwa mu chiwindi ndi kuonjezera magazi mankhwala ndende.
Fluoroquinolone antibacterial mankhwala. Amagwiritsidwa ntchito pa matenda a bakiteriya a ziweto ndi nkhuku komanso matenda a mycoplasma.
jekeseni mu mnofu: Mlingo umodzi, 0.025ml pa 1kg thupi la ng'ombe, nkhosa ndi nkhumba; 0.025 ~ 0.05ml agalu, amphaka ndi akalulu. Gwiritsani ntchito 1 mpaka 2 pa tsiku kwa masiku 2 mpaka 3.
1. Kuwonongeka kwa chichereŵechereŵe m'zinyama zazing'ono, zomwe zimakhudza kukula kwa mafupa ndi kuchititsa kupunduka ndi kupweteka.
2. Zomwe zimachitikira m'mimba zimaphatikizapo kusanza, kusowa kwa njala, kutsekula m'mimba komanso posachedwapa.
3. Zomwe zimachitika pakhungu zimaphatikizapo erythema, pruritus, urticaria ndi photosensitivity.
4. Zotsatira zoyipa, ataxia, kugwidwa kumawoneka mwa agalu ndi amphaka.
1. Imakhala ndi mphamvu yosangalatsa yapakati, kupangitsa khunyu, ndipo iyenera kugwiritsidwa ntchito mosamala agalu akhunyu.
2. Nyama zodya nyama ndi nyama zomwe zili ndi vuto la impso ziyenera kugwiritsidwa ntchito mosamala, zomwe nthawi zina zingayambitse mkodzo wa crystalline.
3. Izi sizoyenera akavalo. Ma jakisoni a intramuscular ndi owopsa osakhalitsa.
4. Izi siziyenera kugwiritsidwa ntchito kwa agalu asanakwanitse masabata 8.
5. Mankhwala osamva mankhwala a mankhwalawa akuwonjezeka ndipo sayenera kugwiritsidwa ntchito mu subtherapeutic mlingo kwa nthawi yaitali.
