Pharmacodynamics flufenicol ndi mankhwala ophatikizika osiyanasiyana.
Aminools, bacteriosuppressor, ndipo amachita pomanga ndi ribosome 50s subunit kuti aletse kaphatikizidwe ka mapuloteni a bakiteriya. Lili ndi mphamvu yolimbana ndi mabakiteriya osiyanasiyana a gram-positive ndi gram-negative. Pasteurella hemolyticus, pasteurella multocida ndi actinobacillus suis pleuropneumoniae anali okhudzidwa kwambiri ndi flufenicol. In vitro, antimicrobial action ya flufenicol motsutsana ndi tizilombo tambiri ndi yofanana kapena yamphamvu kuposa ya sulfenicol, ndipo mabakiteriya ena omwe samva ma aminools chifukwa cha acetylation, monga escherichia coli ndi klebsiella pneumoniae, amathabe kumva flufenicol.
Amagwiritsidwa ntchito kwambiri pa matenda a bakiteriya a nkhumba, nkhuku ndi nsomba zomwe zimayambitsidwa ndi mabakiteriya okhudzidwa, monga matenda opuma a ng'ombe ndi nkhumba chifukwa cha pasteurella hemolyticus, pasteurella multocida ndi actinobacillus pleuropneumoniae. typhoid ndi paratyphoid chifukwa salmonella, nkhuku kolera, nkhuku woyera kamwazi, colibacillosis, etc.; nsomba pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis ndi mabakiteriya ena chifukwa nsomba bakiteriya septicemia, enteritis, erythroderma ndipo posachedwapa.
Pharmacokinetics flufenicol imatengedwa mwachangu ndi makonzedwe amkati, ndipo ndende yochizira imatha kufikika m'magazi patatha pafupifupi ola limodzi, ndipo kuchuluka kwa magazi kumafika pakatha maola 1 mpaka 3. The bioavailability ndi oposa 80%. Flufenicol imafalitsidwa kwambiri mwa nyama ndipo imatha kudutsa chotchinga chamagazi ndi ubongo. Imatulutsidwa makamaka mumkodzo mu mawonekedwe ake oyambirira komanso pang'ono mu ndowe.
1. Macrolides ndi lincoamines ali ndi chandamale chofanana ndi mankhwalawa, amaphatikizidwa ndi bakiteriya ribosome 50s subunit, ndipo amatha kutulutsa zotsatira zotsutsana nazo zikaphatikizidwa.
2. Zitha kusokoneza ntchito ya penicillin kapena aminoglycosides, koma sizinatsimikizidwe mu nyama.
Mankhwala a Amidoalcohol, omwe amakhudzidwa kwambiri ndi Pasteurella hemolyticus, Pasteurella multocida ndi actinobacillus pleuropneumoniae, omwe amagwiritsidwa ntchito pa matenda a Pasteurella ndi Escherichia coli.
Mu mnofu jekeseni: 1 mlingo, pa 1kg thupi, 0,2ml nkhuku, 0,15 ~ 0.2ml nkhosa ndi nkhumba, 0,075 ~ 0.1ml akavalo ndi ng'ombe. Kamodzi pa maola 48 aliwonse, kawiri motsatizana. Nsomba 0.005 mpaka 0.01ml kamodzi patsiku.
1. Mankhwalawa ali ndi mphamvu ya immunosuppressive pamene amagwiritsidwa ntchito kuposa mlingo woyenera.
2. Ili ndi kawopsedwe ka mwana wosabadwayo, ndipo iyenera kugwiritsidwa ntchito mosamala panthawi yomwe ili ndi pakati komanso zoweta zoyamwitsa.
1. Nthawi yoikira nkhuku ndiyoletsedwa.
2. nyama ndi kwambiri akusowa chitetezo kapena katemera nthawi ayenera zoletsedwa.
3. Nyama ndi aimpso insufficiency ayenera bwino kuchepetsedwa kapena yaitali makonzedwe imeneyi nthawi.
