10% jakisoni wa Iron Dextran

Pharmacodynamic iron ndiye chigawo chachikulu cha hemoglobin ndi myoglobin. Hemoglobin ndiye chotengera chachikulu cha okosijeni m'maselo ofiira a magazi. Myoglobin ndi kumene maselo a minofu amasunga mpweya kuti athandize kupereka ku minofu panthawi yochita masewera olimbitsa thupi. Ma enzymes ambiri ndi zinthu zomwe zimakhudzidwa ndi tricarboxylic acid cycle zimakhala ndi chitsulo kapena zimagwira ntchito pamaso pa chitsulo. Choncho, kuwonjezera pa kufulumira kwa kaphatikizidwe ka hemoglobini, zizindikiro zokhudzana ndi kusowa kwachitsulo ndi kuchepa kwa michere yomwe imakhala ndi iron, monga kuchepa kwa kukula, kusokonezeka kwa khalidwe, ndi kufooka kwa thupi, zikhoza kukonzedwa pang'onopang'ono pambuyo powonjezera chitsulo m'zinyama zopanda iron. Pharmacokinetic iron ya jekeseni imatengedwa mwachangu kuposa chitsulo chapakamwa; pambuyo jekeseni mu mnofu wa iron dextran, kuchuluka kwa magazi kunafika pachimake pa maola 24-48, ndipo molekyu yake inali yaikulu. Iwo odzipereka ndi mitsempha yodutsitsa madzi ziwiya ndiyeno anasamutsa mu magazi, ndi magazi ndende chinawonjezeka pang`onopang`ono; ikalowa m'mitsempha kapena mumtsempha m'magazi, imakhala ya phagocytic ndikuwola kukhala iron ndi dextran ndi mononuclear phagocytic cell system. Pambuyo mayamwidwe ayoni chitsulo ndi oxidized kuti ayoni ferric ndi ceruloplasmin m'magazi, ndiyeno kumanga transferrin zolandilira, kulowa maselo mu mawonekedwe a pinocytosis kwa maselo hematopoietic, kapena kudziunjikira mu mawonekedwe a ferritin kapena hemosiderin mu chiwindi, ndulu, m`mafupa ndi mononuclear ena mononuclear kachitidwe phago. Mlingo womanga mapuloteni ndi wokwera kwambiri mu hemoglobin, koma otsika mu myoglobin, ma enzymes ndi mapuloteni onyamula chitsulo, komanso ferritin kapena hemosiderin otsika.