Pharmacodynamic lincomycin ndi wa lincoamine maantibayotiki, ndi bacteriostatic wothandizila, mabakiteriya tcheru monga staphylococcus aureus (kuphatikizapo penicillin zosagwira mitundu), streptococcus, pneumococcus, bacillus anthracis, erysipelas suis, mycoplasma mycoplasma, mycoplasma, mycoplasma, sulfosis synovialis), leptospirosis ndi mabakiteriya anaerobic (monga clostridium difficile, clostridium tetanus, clostridium percapsulatus ndi actinomyces yambiri). Imagwira makamaka pagulu la 50s la bakiteriya ribosome, ndipo imakhala ndi antibacterial effect poletsa kufalikira kwa unyolo wa peptide ndikusokoneza kaphatikizidwe ka mapuloteni.
Kutsekemera kunali kofulumira pambuyo pa jekeseni wa intramuscular, ndi jekeseni imodzi ya intramuscular ya 11mg / kg mu nkhumba ndi nsonga yamagazi ya 6.25μg / ml. Kumanga kwa mapuloteni a plasma kunali 57% - 72%. Amagawidwa kwambiri mu vivo, ndi chiwerengero chowonekera cha 2.8 l / kg mu nkhumba. Amagawidwa kwambiri m'madzi am'thupi ndi m'matumbo osiyanasiyana (kuphatikiza fupa), pomwe kuchuluka kwa chiwindi ndi impso ndikokwera kwambiri, ndipo kuchuluka kwa mankhwala a minofu kumakhala kokwera kangapo kuposa kuchuluka kwa seramu nthawi yomweyo. Iwo akhoza kulowa latuluka, koma si kophweka kudutsa magazi-ubongo chotchinga, ndipo n'zovuta kufika ogwira ndende ya mankhwala mu cerebrospinal madzimadzi pamene kutupa kumachitika. Ikhoza kugawidwa ku mkaka, ndipo ndende mu mkaka ndi chimodzimodzi ndi madzi a m'magazi. Mbali ya mankhwala zimapukusidwa mu chiwindi, ndi mankhwala mawonekedwe ndi metabolites ndi excreted kudzera mu ndulu, mkodzo ndi mkaka. Excretion mu chopondapo akhoza kuchedwa kwa masiku angapo, choncho ali ndi chopinga kwambiri matumbo tcheru tizilombo.
1. Akaphatikizidwa ndi gentamicin, ali ndi synergistic zotsatira za mabakiteriya gram-positive monga staphylococcus ndi streptococcus.
2. Pamene pamodzi aminoglycosides ndi polypeptide mankhwala, mwina kumapangitsanso kutsekereza zotsatira neuromuscular mphambano. Kuphatikizidwa ndi erythromycin kumatsutsana kwambiri, chifukwa malo ake ndi ofanana, ndipo erythromycin imakhala yogwirizana kwambiri ndi gawo la 50s la ribosomes la bakiteriya kuposa mankhwalawa.
3. Siziyenera kuphatikizidwa ndi mankhwala oletsa kutsekula m'mimba omwe amalepheretsa matumbo a peristalsis ndipo amakhala ndi dongo loyera. 4. Pali kusagwirizana ndi kanamycin, neomycin, ndi zina zotero.
Mankhwala a Lincoamine. Pakuti gram zabwino mabakiteriya matenda, Angagwiritsidwenso ntchito treponemosis ndi mycoplasma ndi matenda ena.
Mu mnofu jekeseni: Mlingo umodzi, 0.0165 ~ 0.033ml pa 1kg kulemera kwa akavalo ndi ng'ombe, 0.033ml nkhosa ndi nkhumba, kamodzi patsiku; 0.033ml kwa agalu ndi amphaka, kawiri pa tsiku, kwa masiku 3 mpaka 5.
Jekeseni mu mnofu angayambitse kutsegula m'mimba kwakanthawi kapena chimbudzi chofewa. Ngakhale kuti ndizosowa, njira zoyenera ziyenera kuchitidwa pofuna kupewa kutaya madzi m'thupi ngati zichitika.
