Pharmacodynamic damamycin ndi aminoglycoside maantibayotiki, ndipo ali zolimbitsa chopinga zotsatira zosiyanasiyana gram alibe bacilli, monga escherichia coli, salmonella, shigella, proteus ndi zina zotero. Zimakhudzidwa ndi streptococcus, pneumococcus, staphylococcus epidermidis ndi mycoplasma (monga mycoplasma gallinarum, mycoplasma turkey, mycoplasma synovialis, etc.). Nthawi zambiri imakhala yosakhudzidwa ndi streptococcus viridis ndi staphylococcus aureus. Nthawi zambiri imalimbana ndi pseudomonas aeruginosa ndi treponemas. Mabakiteriya am'mimba samva kukana kwa megamycin, koma samawonetsa kukana kwa streptomycin. Lincomycin ali wabwino antibacterial ntchito motsutsana anaerobic mabakiteriya, monga clostridium, peptococcus, peptostreptococcus, clostridium kafumbata, clostridium perfringens ndi actinomyces ambiri. Lincomycin makamaka amagwira ntchito pa gawo la 50s la ma ribosomes a bakiteriya, omwe amakhudza kaphatikizidwe ka mapuloteni poletsa kufalikira kwa unyolo wa peptide.
Pharmacokinetics yekha 7% ya lincomycin odzipereka pambuyo mkati makonzedwe, koma amakhala mkulu ndende mu m`mimba thirakiti. Minofu ndende ya mankhwala ndi m`munsi kuposa seramu ndende. Sikophweka kulowa mu cerebrospinal fluid kapena diso, ndipo kuchuluka kwa mapuloteni a plasma sikuli kwakukulu. Mankhwala ambiri amachotsedwa ndi kusefera kwa glomerular mu mawonekedwe awo oyambirira. The bioavailability wa lincomycin ndi 30% ~ 40% ndi osauka mayamwidwe m`kamwa makonzedwe. Mlingo wa mayamwidwe ndi kuchuluka kwa lincomycin zitha kuchepetsedwa pophatikiza chakudya. Nkhuku anapatsidwa 50mg wa mankhwalawa (kusungunuka m'madzi akumwa) pa kilogalamu ya kulemera kwa thupi kwa masiku 7. Pakuyesa, plasma lincomycin inafika 0.14 μ g/ml, pamene daguanmycin inali yochepa kwambiri. Pambuyo pa masiku 7 akuyesa, adadutsa 0.1μg/ml.
1. Kuphatikiza ndi lincomycin, imatha kukulitsa kwambiri ntchito ya antibacterial motsutsana ndi mycoplasma ndikukulitsa mawonekedwe a antibacterial.
2. Kuphatikiza kwa lincomycin ndi anticholinesterase mankhwala kungachepetse mphamvu yomaliza.
3. Kuphatikizidwa ndi erythromycin kumakhala ndi zotsatira zotsutsana.
Mankhwala opha tizilombo. Kwa mabakiteriya a gram-negative, mabakiteriya a gram-positive ndi matenda a mycoplasma.
Chakumwa chosakaniza: 100g ya mankhwalawa wothira madzi 200 ~ 300kg nkhumba ndi 50 ~ 100kg nkhuku kwa masiku 3-5. Kudyetsa mosakaniza: 100g chakudya chosakaniza 100kg cha nkhumba ndi 50kg cha nkhuku, ntchito kwa masiku asanu mpaka 7.
Bzalani chisamaliro chaumoyo: Kuyambira masiku 7 musanabadwe mpaka masiku 7 mutabereka, 100g ya mankhwalawa imasakanizidwa ndi 100kg, kapena 200kg ndi madzi. Chisamaliro cha thanzi la ana a nkhumba: Asanasiya kuyamwitsa ndi kuyamwitsa, 100g sakanizani 100kg, kapena 200kg madzi.
Palibe zoyipa zomwe zawonedwa zikagwiritsidwa ntchito molingana ndi momwe amagwiritsidwira ntchito komanso mlingo wake.
