Pharmacodynamics semisynthetic macrolide antibiotics kwa Zinyama zamtundu wa temicosin. Ndiwolimba ku mycoplasma, ndipo zotsatira zake za antibacterial ndizofanana ndi tylosin. Mabakiteriya omwe ali ndi gram-positive ndi staphylococcus aureus (kuphatikizapo penicillin-resistant staphylococcus aureus), pneumococcus, streptococcus, anthrax bacillus, swineerysipelas, listeria, clostridium putrefaciens, clostridium emphysema ndi zina zotero. Mabakiteriya osamva gram-negative ndi haemophilus, meningococci, pasteurella ndipo posachedwa. Ntchito yolimbana ndi actinobacillus pleuropneumoniae, pasteurella ndi mycoplasma ya ziweto ndi nkhuku ndi yamphamvu kuposa tylosin. 95% ya mitundu ya pasteurella hemolyticus inali tcheru ndi mankhwalawa.
Pharmacokinetic mayamwidwe mofulumira pambuyo makonzedwe a mkati, yodziwika ndi amphamvu minofu malowedwe, kuchuluka kwa kugawa (kuposa 2l/kg). Kuphatikizika kwake kumakhala kwakukulu m'mapapo, kuchotsera theka la moyo kumatha kufika masiku 1-2, ndipo kuchuluka kwa magazi m'magazi kumasungidwa kwa nthawi yayitali.
(1) Kuphatikiza kwa mankhwalawa ndi epinephrine kungapangitse kufa kwa nkhumba.
(2) Ili ndi cholinga chofanana ndi ma macrolides ena ndi lincoamines, ndipo sayenera kugwiritsidwa ntchito nthawi imodzi.
(3) Kuphatikiza kwa β-lactam kumawonetsa kutsutsa.
Maantibayotiki a Macrolide. Amagwiritsidwa ntchito pochiza actinobacillus, pasteurella ndi mycoplasma matenda a porcine pleuropneumoniae.
Kudyetsa kosakaniza: 1000 ~ 2000g nkhumba pa 1000kg chakudya kwa masiku 15.
(1) Poizoni wa mankhwalawa pa nyama makamaka mtima dongosolo, zomwe zingayambitse tachycardia ndi kufooketsa mphamvu ya systolic.
(2) Matenda a m'mimba omwe amadalira mlingo, monga kusanza, kutsekula m'mimba, kupweteka kwa m'mimba, ndi zina zotero, nthawi zambiri zimachitika pambuyo pa makonzedwe amkati.
